[Potential usefulness of human iPS cells on the generation of platelets]

Nihon Rinsho. 2011 Dec;69(12):2161-5.
[Article in Japanese]

Abstract

Repetitive transfusion of platelets expressing HLA not corresponded to recipient matched often induces anti-HLA antibody-based undesired events including unresponsiveness in platelet transfusion therapy. It is desirable to use platelets derived from HLA-matched iPS cells. In this context, we have recently established an in vitro culture system whereby human pluripotent stem cells can be differentiated into'unique sac-like structures' (ES-/iPS-sacs) containing hematopoietic progenitors generating platelets. Among various iPS clones, we also found critical role of c-MYC in human megakaryopoiesis, leading to efficient platelet production with an intact in vivo functionality of hemostasis and thrombosis within the vessel. We propose that use of HLA-matched hiPS cells may be one of useful strategies for the treatment of thrombocytopenia in patients requiring repeated transfusion.

Publication types

  • English Abstract

MeSH terms

  • Blood Platelets / physiology*
  • Cell Differentiation
  • Cells, Cultured
  • Humans
  • Induced Pluripotent Stem Cells / physiology*
  • Thrombocytopenia / therapy