Alzheimer's disease risk factor complement receptor 1 is associated with depression

Gillian Hamilton; Kathryn L Evans; Donald J Macintyre; Ian J Deary; Anna Dominiczak; Blair H Smith; Andrew D Morris; David J Porteous; Pippa A Thomson

doi:10.1016/j.neulet.2011.12.059

Alzheimer's disease risk factor complement receptor 1 is associated with depression

Neurosci Lett. 2012 Feb 21;510(1):6-9. doi: 10.1016/j.neulet.2011.12.059. Epub 2012 Jan 8.

Authors

Gillian Hamilton¹, Kathryn L Evans, Donald J Macintyre, Ian J Deary, Anna Dominiczak, Blair H Smith, Andrew D Morris, David J Porteous, Pippa A Thomson

Affiliation

¹ Medical Genetics, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, UK. [email protected]

PMID: 22244847
DOI: 10.1016/j.neulet.2011.12.059

Abstract

Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / complications
Alzheimer Disease / genetics*
Depression / complications
Depression / genetics*
Female
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study
Haplotypes / genetics
Humans
Male
Polymorphism, Single Nucleotide / genetics
Receptors, Complement / genetics*
Scotland

Substances

Receptors, Complement

Abstract

Publication types

MeSH terms

Substances

Grants and funding