Abstract
A new lignan glucoside, (+)-(7S,8R,8'R)-lyoniresinol 9-O-β-D-(6″-O-trans-sinapoyl)glucopyranoside (1), and a new iridoid glucoside, 10-O-trans-sinapoylgeniposide (2), together with eight known compounds, were isolated from the fruits of Gardenia jasminoides Ellis. The structures of the isolates were elucidated by extensive spectroscopic studies, including UV, IR, 1D and 2D NMR, ESI-MS, HR-ESI-MS, and CD experiments. The short-term-memory-enhancement activities of some compounds were evaluated on an Aβ transgenic drosophila model.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / drug therapy
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Animals
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Animals, Genetically Modified
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Disease Models, Animal
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Drosophila
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Fruit / chemistry*
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Gardenia / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Memory, Short-Term / drug effects*
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Molecular Structure
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Nootropic Agents / isolation & purification*
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Nootropic Agents / pharmacology
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Nootropic Agents / therapeutic use
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Phytotherapy
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
Substances
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(7S,8R,8'R)-lyoniresinol 9-O-beta-D-(6''-O-trans-sinapoyl)glucopyranoside
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10-O-trans-sinapoylgeniposide
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Glycosides
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Iridoids
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Lignans
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Nootropic Agents
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Plant Extracts