Hybrid liposomes affect cellular lipid constituents and caveolae structures

Ke Cao; Kouji Tanaka; Yuji Komizu; Keiko Tamiya-Koizumi; Takashi Murate; Ryuichi Ueoka; Mamoru Kyogashima; Jiro Usukura; Takashi Takahashi; Motoshi Suzuki

doi:10.1016/j.bmcl.2011.12.093

Hybrid liposomes affect cellular lipid constituents and caveolae structures

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1731-3. doi: 10.1016/j.bmcl.2011.12.093. Epub 2011 Dec 28.

Authors

Ke Cao¹, Kouji Tanaka, Yuji Komizu, Keiko Tamiya-Koizumi, Takashi Murate, Ryuichi Ueoka, Mamoru Kyogashima, Jiro Usukura, Takashi Takahashi, Motoshi Suzuki

Affiliation

¹ Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine, Nagoya, Japan.

PMID: 22248855
DOI: 10.1016/j.bmcl.2011.12.093

Abstract

We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Caveolae / chemistry*
Cell Line, Tumor
Cell Survival
Humans
Lipids / chemistry*
Liposomes / chemistry*
Models, Biological
Neoplasms / chemistry*
Signal Transduction
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

Lipids
Liposomes