Functional outcomes after chemoradiotherapy of laryngeal and pharyngeal cancers

Curr Oncol Rep. 2012 Apr;14(2):158-65. doi: 10.1007/s11912-012-0216-1.

Abstract

Organ preservation regimens that combine chemotherapy and radiotherapy (chemoradiotherapy) are increasingly used as the primary treatment of laryngeal and pharyngeal cancers. Meta-analytic data show a survival benefit with combined modality therapy, but the functional sequelae can be significant. Dysphagia is recognized as a common and often devastating late effect of chemoradiotherapy. This review examines functional outcomes after chemoradiotherapy for laryngeal and pharyngeal cancers, with a particular emphasis on dysphagia. Topics examined include the burden of dysphagia after chemoradiation, pathophysiology of dysphagia, baseline functioning, recommendations to improve long-term function, and voice outcomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chemoradiotherapy / adverse effects*
  • Clinical Trials as Topic
  • Constriction, Pathologic / etiology
  • Deglutition Disorders / etiology*
  • Deglutition Disorders / physiopathology
  • Esophageal Stenosis / etiology
  • Humans
  • Laryngeal Neoplasms / therapy*
  • Pharyngeal Diseases / etiology
  • Pharyngeal Neoplasms / therapy*
  • Voice Disorders / etiology*
  • Voice Disorders / physiopathology