Dynamic imaging of ictal rhythmic activity using dense-array EEG

Annu Int Conf IEEE Eng Med Biol Soc. 2011:2011:8271-4. doi: 10.1109/IEMBS.2011.6092039.

Abstract

Electroencephalogram (EEG) is an important component of the pre-surgical evaluation in the treatment of medically intractable epilepsy. However, clinical EEG uses 19 to 32 electrodes that significantly limits its localization ability. Recent development of dense-array recording techniques has suggested that increased spatial sampling rate improves the accuracy of source localization. In the current study, we proposed a 76-channel EEG system for the long-term monitoring of epilepsy patients, and proposed a dynamic seizure imaging (DSI) technique to image the ictal rhythmic activity that may evolve through time, space and frequency. We tested the system in a cohort of 8 patients and our results show that the DSI estimated the seizure activity in good correlation with intracranial recordings, successful surgery outcomes and other clinical evidence. The proposed dense-array recording and DSI imaging approach enable a non-invasive but quantitative imaging of continuous seizure activity. The results suggest that DSI may potentially be useful to assist the pre-surgical evaluation in patients with intractable epilepsy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Electrodes
  • Electroencephalography / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Scalp
  • Seizures / physiopathology*
  • Time Factors
  • Young Adult