[Combination of bla(VIM-1) and qnrS2 on the same plasmid in Klebsiella oxytoca and Klebsiella pneumoniae isolates in Seville]

Enferm Infecc Microbiol Clin. 2012 May;30(5):246-8. doi: 10.1016/j.eimc.2011.09.020. Epub 2012 Jan 16.
[Article in Spanish]

Abstract

Background: Combined resistance to quinolones and β-lactams is common in Enterobacteriaceae. The appearance in enterobacteria coding for metallo-β-lactamases and determinants of plasmid-mediated quinolone resistance are an emerging problem in our country.

Methods: The susceptibility was determined by E-test. The resistance genes were detected by PCR and the corresponding plasmids were characterised.

Results: This study describes 2 strains (1 Klebsiella oxytoca, 1 Klebsiella pneumoniae) carrying the genes qnrS2 and blaVIM-1 in a transferable plasmid of 70-Kb isolated in surveillance cultures at the University Hospital Virgen Macarena in Seville.

Conclusion: This is the first combination of qnrS2 and bla(VIM-1) on the same non-typeable plasmid isolated in our centre.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • Klebsiella oxytoca / drug effects*
  • Klebsiella oxytoca / genetics*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics*
  • Plasmids / genetics*
  • Spain
  • beta-Lactamases / genetics

Substances

  • Bacterial Proteins
  • Qnr protein, Klebsiella pneumoniae
  • VIM-1 metallo-beta-lactamase
  • beta-Lactamases