Abstract
Brain natriuretic peptide (BNP) is a major marker for evaluating cardiac function and has been widely used in clinical practice. Recent researches show that BNP is also useful for identification of sudden cardiac death in forensic pathology. This article reviews the molecular structure and biological characteristics of the BNP and its application as a functional indicate in forensic medicine. It shows that the expression of BNP in cardiac muscles, together with the expression of BNP in blood and pericardium liquid can be used to evaluate the pathological physiology changes and dysfunction degrees of the heart during the cardiac sudden death.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Autopsy
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Biomarkers
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Death, Sudden, Cardiac*
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Forensic Pathology*
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Heart Diseases / diagnosis*
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Heart Diseases / metabolism
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Heart Diseases / physiopathology
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Heart Failure / diagnosis
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Heart Failure / metabolism
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Heart Failure / physiopathology
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Humans
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Immunohistochemistry
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Molecular Sequence Data
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Myocardium / metabolism*
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Myocardium / pathology
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Natriuretic Peptide, Brain / blood
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Natriuretic Peptide, Brain / genetics
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Natriuretic Peptide, Brain / metabolism*
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Peptide Fragments / blood
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Peptide Fragments / genetics
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Peptide Fragments / metabolism
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Pericardium / metabolism
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Postmortem Changes
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
Substances
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Biomarkers
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Peptide Fragments
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RNA, Messenger
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pro-brain natriuretic peptide (1-76)
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Natriuretic Peptide, Brain