Protecting group free, stereocontrolled synthesis of β-halo-enamides

J Org Chem. 2012 Mar 2;77(5):2149-58. doi: 10.1021/jo202130e. Epub 2012 Feb 14.

Abstract

Enamides, dienamides, and enynamides are important building blocks in synthetic, biological, and medicinal chemistry as well as materials science. Despite the extensive breath of their potential utility in synthetic chemistry, there is a lack of simple, high-yielding methods to deliver them efficiently and as single isomers. In this paper, we present a novel, protecting group free, efficient, and stereoselective approach to the generation of β-halo-enamides. The methodology presented provides a robust synthetic platform from which E- or Z-enamides can be generated in good yields and with complete stereocontrol.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism

Substances

  • Amides