We investigated whether physiological data can be used for predicting chronic obstructive pulmonary disease (COPD) exacerbations. Home measurements from 57 patients were analysed, during which 10 exacerbations occurred in nine patients. A total of 273 different features were evaluated for their discrimination abilities between periods with and without exacerbations. The analysis showed that if a sensitivity level of 70% is considered to be acceptable, then the specificity was 95% and the AUC was 0.73, i.e. it is possible to discriminate between periods of exacerbation and periods without. A system capable of predicting risk could provide support to COPD patients in their tele-rehabilitation.