Parkinson's disease is the most common neurodegenerative movement disorder. Although it is mostly a sporadic disorder, 15-30% of all cases are linked to a genetic background. On this ground, several cellular and animal models have been developed to investigate disease etiology and pathogenetic mechanisms. Nevertheless, several clinical issues cannot be investigated using models, thus making post-mortem studies necessary to complete the picture.
© 2012 The Authors Journal compilation © 2012 FEBS.