Background: A disintegrin and metalloprotease 33 (ADAM33) has recently been suspected to be associated with psoriasis.
Objective: To study the association between ADAM33 and psoriasis in the northeastern Chinese Han population.
Methods: We genotyped six common single nucleotide polymorphisms from ADAM33 in 400 psoriasis cases and 398 controls using the Multiplex SNaPSHOT method.
Results: We observed an increased risk of psoriasis to be associated with the rs2787094CC CG, rs528557CC CG genotypes (p < 0.05) and 3 haplotypes (H1, H3, and H5; p < 0.05). We also found that the rs512625AA rs612709AA GA genotypes and haplotype H8 may be protective against psoriasis (p < 0.05). Among these genotypes, rs2787094CC exhibited the strongest association with psoriasis (OR = 2.537,being the highest OR, p = 0.0014).
Conclusions: ADAM33 polymorphisms are associated with psoriasis in the northeastern Chinese Han population.
Copyright © 2012 S. Karger AG, Basel.