Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1660-3. doi: 10.1016/j.bmcl.2011.12.114. Epub 2012 Jan 2.

Abstract

Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages, and their IC(50) values ranged from 9.85 to 13.95 μg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alpinia / chemistry*
  • Animals
  • Fruit / chemistry
  • Inhibitory Concentration 50
  • Macrophages / drug effects*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Sesquiterpenes, Eudesmane / chemistry*
  • Sesquiterpenes, Eudesmane / pharmacology*

Substances

  • Sesquiterpenes, Eudesmane
  • Nitric Oxide