Abstract
The mutagenic activities of the trans-1,2- and 3,4-diols of dibenz(a,c)anthracene, both of which could yield 'bay-region' diol-epoxides on further metabolism, were lower than those of the parent hydrocarbon and of the related 10,11-diol.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Benz(a)Anthracenes / pharmacology*
-
Dihydroxydihydrobenzopyrenes / pharmacology*
-
Microsomes, Liver / drug effects*
-
Molecular Structure
-
Mutagenicity Tests
-
Rats
-
Salmonella typhimurium / drug effects*
-
Structure-Activity Relationship
Substances
-
Benz(a)Anthracenes
-
Dihydroxydihydrobenzopyrenes
-
benzanthracene-10,11-dihydrodiol
-
3,4-dihydro-3,4-dihydroxybenzo(a,i)pyrene
-
1,2-dihydro-1,2-dihydroxydibenzo(a)pyrene