Low-titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half-life after immune tolerance induction

J Thromb Haemost. 2012 Apr;10(4):706-8. doi: 10.1111/j.1538-7836.2012.04645.x.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antibodies / blood*
  • Blood Chemical Analysis / methods*
  • Coagulants / adverse effects
  • Coagulants / blood
  • Coagulants / immunology
  • Coagulants / pharmacokinetics*
  • Factor VIII / adverse effects
  • Factor VIII / immunology
  • Factor VIII / pharmacokinetics*
  • Half-Life
  • Hemophilia A / blood
  • Hemophilia A / drug therapy*
  • Hemophilia A / immunology
  • Hemorrhage / chemically induced
  • Hemorrhage / prevention & control
  • Humans
  • Immune Tolerance*
  • Infusions, Intravenous
  • Predictive Value of Tests
  • Sensitivity and Specificity

Substances

  • Antibodies
  • Coagulants
  • Factor VIII