Abstract
Tako-Tsubo cardiomyopathy (TTC) occurs particularly in post-menopausal women, being precipitated in many cases by severe emotional stress. We describe six patients in whom TTC occurred in association with therapeutic ingestion or overdose of the serotonin/noradrenaline reuptake inhibitor venlafaxine, or its metabolite desvenlafaxine. Importantly, two of the six cases were not post-menopausal women. An increased risk of TTC may account for some of the reported cardiovascular adverse effects of venlafaxine and similar agents.
Copyright © 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Cyclohexanols / adverse effects*
-
Cyclohexanols / therapeutic use
-
Desvenlafaxine Succinate
-
Drug Overdose
-
Female
-
Humans
-
Male
-
Middle Aged
-
Natriuretic Peptide, Brain / blood
-
Normetanephrine / blood
-
Peptide Fragments / blood
-
Selective Serotonin Reuptake Inhibitors / adverse effects*
-
Selective Serotonin Reuptake Inhibitors / therapeutic use
-
Takotsubo Cardiomyopathy / chemically induced*
-
Takotsubo Cardiomyopathy / physiopathology
-
Venlafaxine Hydrochloride
Substances
-
Cyclohexanols
-
Peptide Fragments
-
Serotonin Uptake Inhibitors
-
pro-brain natriuretic peptide (1-76)
-
Normetanephrine
-
Natriuretic Peptide, Brain
-
Venlafaxine Hydrochloride
-
Desvenlafaxine Succinate