Peroxide-mediated transition-metal-free direct amidation of alcohols with nitroarenes

Org Lett. 2012 Feb 17;14(4):984-7. doi: 10.1021/ol203211k. Epub 2012 Jan 31.

Abstract

An unusual direct amidation of alcohols with nitroarenes mediated by peroxides has been discovered. The reaction tolerated a wide range of functionalities, and various aromatic amides were obtained in moderate to good yields in the absence of transition-metal catalyst. The peroxides and solvents had a significant impact on the reaction yield.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Amination
  • Catalysis
  • Hydrocarbons, Aromatic / chemistry*
  • Molecular Structure
  • Nitrogen Compounds / chemistry*
  • Peroxides / chemistry*
  • Solvents / chemistry

Substances

  • Alcohols
  • Hydrocarbons, Aromatic
  • Nitrogen Compounds
  • Peroxides
  • Solvents