Abstract
B cell lymphoma with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (DLBCL/BL) is a new lymphoma entity which is recognized in the current World Health Organization (WHO) classification (2008). We report a case of a primary central nervous system lymphoma (PCNSL) with findings consistent with DLBCL/BL. It is characterized by a very aggressive clinical course, and a widespread multifocal involvement of the CNS. Our case shows that a DLBCL/BL can manifest in the CNS alone without any systemic involvement.
Keywords:
Lymphoma; central nervous system.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Central Nervous System Neoplasms / genetics
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Central Nervous System Neoplasms / pathology*
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Central Nervous System Neoplasms / physiopathology*
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Fatal Outcome
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Genes, bcl-2
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Humans
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Immunohistochemistry
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In Situ Hybridization, Fluorescence
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Lymphoma, B-Cell / genetics
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Lymphoma, B-Cell / pathology*
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Lymphoma, B-Cell / physiopathology*
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Male
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Neoplasm Staging
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Proto-Oncogene Proteins c-myc / genetics
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Radiotherapy
Substances
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Proto-Oncogene Proteins c-myc