Abstract
This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2%) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Diethylnitrosamine
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Down-Regulation / drug effects
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Fungi / chemistry*
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Liver Neoplasms, Experimental / chemically induced
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Liver Neoplasms, Experimental / genetics
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Liver Neoplasms, Experimental / metabolism
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Liver Neoplasms, Experimental / prevention & control*
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Male
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Medicine, Chinese Traditional
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RNA, Messenger / genetics
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Random Allocation
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Rats
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Rats, Sprague-Dawley
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Survival Rate
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism*
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alpha-Fetoproteins / metabolism
Substances
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Afp protein, rat
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Antineoplastic Agents, Phytogenic
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RNA, Messenger
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Tumor Suppressor Protein p53
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alpha-Fetoproteins
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Diethylnitrosamine
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Alanine Transaminase