Symptom-specific attentional bias to threatening stimuli in obsessive-compulsive disorder

Compr Psychiatry. 2012 Aug;53(6):783-8. doi: 10.1016/j.comppsych.2011.12.005. Epub 2012 Jan 31.

Abstract

Objective: There is mixed evidence as to whether patients with obsessive-compulsive disorder (OCD) have excessive attentional engagement and emotional response to OCD-related stimuli in the environment. Here we investigate the occurrence of an attentional bias toward specific OCD-related stimuli and its relationship with obsessive-compulsive symptom dimensions.

Methods: Forty-eight patients with OCD participated in an attentional bias task containing OCD- and non-OCD-related stimuli and had their performance compared with that of 24 age-, sex-, and education-matched healthy control subjects. Severity of obsessive-compulsive and comorbid depressive symptoms was assessed using the Obsessive-Compulsive Inventory-Revised and the Beck Depression Inventory, respectively.

Results: Although there were significant and almost significant group effects on the reaction time (RT) toward OCD- and non-OCD-related figures, respectively, no difference between patients with OCD and controls was noted with regard to RT toward OCD-related figures minus RT toward non-OCD-related figures. Nevertheless, within the OCD group, partial correlational analysis controlled for age and severity of depression unveiled positive correlations between (1) obsessional symptoms and RT toward checking-related pictures and (2) ordering symptoms and RT toward ordering-related pictures.

Conclusions: The positive correlations between RT to content-specific stimuli and the severity of corresponding obsessive-compulsive symptoms suggest that patients with OCD experience difficulty in disengaging attention from personally salient stimuli.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Attention / physiology*
  • Cues
  • Depression / complications
  • Depression / psychology*
  • Emotions / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Obsessive-Compulsive Disorder / complications
  • Obsessive-Compulsive Disorder / psychology*
  • Photic Stimulation
  • Psychiatric Status Rating Scales
  • Reaction Time / physiology
  • Severity of Illness Index