Synthesis of cyclic peptides and cyclic proteins via ligation of peptide hydrazides

Chembiochem. 2012 Mar 5;13(4):542-6. doi: 10.1002/cbic.201100580. Epub 2012 Feb 2.

Abstract

Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower costs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Hydrazines / chemistry*
  • Molecular Structure
  • Oligopeptides / chemistry*
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Proteins / chemical synthesis*
  • Proteins / chemistry

Substances

  • Hydrazines
  • Oligopeptides
  • Peptides, Cyclic
  • Proteins