FGF21 and the second coming of PPARγ

Li Qiang; Domenico Accili

doi:10.1016/j.cell.2012.01.020

FGF21 and the second coming of PPARγ

Cell. 2012 Feb 3;148(3):397-8. doi: 10.1016/j.cell.2012.01.020.

Authors

Li Qiang¹, Domenico Accili

Affiliation

¹ Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

Abstract

Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPARγ agonists?

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