Hollow spherical mesoporous phosphosilicate nanoparticles as a delivery vehicle for an antibiotic drug

Chem Commun (Camb). 2012 Mar 18;48(23):2891-3. doi: 10.1039/c2cc17181c. Epub 2012 Feb 7.

Abstract

Mesoporous phosphosilicate nanoparticles of hollow sphere architecture have been prepared hydrothermally for the first time under acidic pH conditions and this material is found to be efficient in encapsulating an antibiotic drug and its controlled release at physiological pH for possible cargo delivery applications.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Cell Line, Tumor
  • Drug Carriers / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Porosity
  • Silicates / chemistry*
  • Silicon Dioxide / chemistry

Substances

  • Anti-Bacterial Agents
  • Drug Carriers
  • SBA-15
  • Silicates
  • Silicon Dioxide