Osteophilic multilayer coatings for accelerated bone tissue growth

Adv Mater. 2012 Mar 15;24(11):1445-50. doi: 10.1002/adma.201104475. Epub 2012 Feb 7.

Abstract

Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bone Development*
  • Bone Morphogenetic Protein 2 / chemistry
  • Chitosan / chemistry
  • Coated Materials, Biocompatible / chemistry*
  • Durapatite / chemistry
  • Humans
  • Materials Testing
  • Membranes, Artificial*
  • Nanoparticles / chemistry
  • Polymers / chemistry
  • Recombinant Proteins / chemistry

Substances

  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Coated Materials, Biocompatible
  • Membranes, Artificial
  • Polymers
  • Recombinant Proteins
  • Chitosan
  • Durapatite