Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

J Med Chem. 1990 Nov;33(11):2952-6. doi: 10.1021/jm00173a007.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anticholesteremic Agents / chemical synthesis*
  • Anticholesteremic Agents / chemistry
  • Anticholesteremic Agents / pharmacology
  • Butyrates / chemical synthesis*
  • Butyrates / chemistry
  • Butyrates / pharmacology
  • Cholesterol / biosynthesis*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology
  • Liver / enzymology
  • Molecular Structure
  • Organophosphorus Compounds / chemical synthesis*
  • Organophosphorus Compounds / chemistry
  • Organophosphorus Compounds / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Anticholesteremic Agents
  • Butyrates
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Indoles
  • Organophosphorus Compounds
  • SQ 33600
  • Cholesterol