Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues

Sameh Magdeldin; Tadashi Yamamoto

doi:10.1002/pmic.201100550

Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues

Proteomics. 2012 Apr;12(7):1045-58. doi: 10.1002/pmic.201100550.

Authors

Sameh Magdeldin¹, Tadashi Yamamoto

Affiliation

¹ Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.

Abstract

Formalin-fixed paraffin-embedded (FFPE) tissue specimens comprise a potentially valuable resource for both prospective and retrospective biomarker discovery. Unlocking the proteomic profile of clinicopathological FFPE tissues is a critically essential step for annotating clinical findings and predicting biomarkers for ultimate disease prognosis and therapeutic follow-up.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acids / analysis
Animals
Formaldehyde*
Humans
Mice
Paraffin Embedding*
Protein Stability
Proteome / analysis*
Proteome / chemistry*
Proteomics / methods*
Proteomics / standards
Reproducibility of Results
Solvents / chemistry

Substances

Amino Acids
Proteome
Solvents
Formaldehyde