Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells

Angew Chem Int Ed Engl. 2012 Mar 19;51(12):2874-7. doi: 10.1002/anie.201106334. Epub 2012 Feb 14.

Authors

Tanja Wirth¹, Kianga Schmuck, Lutz F Tietze, Stephan A Sieber

Affiliation

¹ Department Chemie, Center for Integrated Protein Science, Institute of Advanced Studies, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.

PMID: 22334487
DOI: 10.1002/anie.201106334

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde Dehydrogenase 1 Family
Antineoplastic Agents, Alkylating / chemistry
Antineoplastic Agents, Alkylating / therapeutic use
Antineoplastic Agents, Alkylating / toxicity
Binding Sites
Cell Line, Tumor
Cell Proliferation / drug effects
Duocarmycins
Humans
Indoles / chemistry
Indoles / therapeutic use
Indoles / toxicity
Isoenzymes / antagonists & inhibitors*
Isoenzymes / genetics
Isoenzymes / metabolism
Lung Neoplasms / drug therapy
Pyrroles / chemistry
Pyrroles / therapeutic use
Pyrroles / toxicity
Recombinant Proteins / antagonists & inhibitors
Recombinant Proteins / genetics
Recombinant Proteins / metabolism
Retinal Dehydrogenase / antagonists & inhibitors*
Retinal Dehydrogenase / genetics
Retinal Dehydrogenase / metabolism
Tandem Mass Spectrometry

Substances

Antineoplastic Agents, Alkylating
Duocarmycins
Indoles
Isoenzymes
Pyrroles
Recombinant Proteins
duocarmycin SA
Aldehyde Dehydrogenase 1 Family
ALDH1A1 protein, human
Retinal Dehydrogenase