Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes

Mol Biochem Parasitol. 2012 May;183(1):1-7. doi: 10.1016/j.molbiopara.2012.02.001. Epub 2012 Feb 11.

Abstract

This review is designed to summarize the information on monoamine-dependent paralysis as a target for anthelmintic development, examine the conservation of monoamine receptors in the genomes of both free-living and parasitic nematodes, and highlight the utility of the Caenorhabditis elegans model system for dissecting the monoaminergic modulation of locomotory decision-making.

Publication types

  • Review

MeSH terms

  • Amines / pharmacology*
  • Animals
  • Antinematodal Agents / pharmacology*
  • Antinematodal Agents / therapeutic use
  • Drug Discovery*
  • Helminth Proteins / agonists
  • Helminth Proteins / genetics
  • Helminth Proteins / metabolism
  • Humans
  • Nematoda / drug effects*
  • Nematoda / genetics
  • Nematoda / metabolism*
  • Nematode Infections / drug therapy
  • Phylogeography
  • Receptors, Cell Surface / agonists
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction

Substances

  • Amines
  • Antinematodal Agents
  • Helminth Proteins
  • Receptors, Cell Surface