New isoprenylated flavones and stilbene derivative from Artocarpus hypargyreus

Chem Biodivers. 2012 Feb;9(2):394-402. doi: 10.1002/cbdv.201100072.

Abstract

Three new isoprenylated flavones, hypargyflavones A-C (1-3, resp.), and one novel stilbene derivative, hypargystilbene A (4), together with seven known compounds, 5-11, were isolated from the stems of Artocarpus hypargyreus Hance. The structures were elucidated by spectroscopic methods. Hypargyflavone A (1), cudraflavone C (8), brosimone I (10), and norartocarpin (11) showed inhibitory effects on pancreatic lipase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Artocarpus / chemistry*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology*
  • Flavones / chemistry
  • Flavones / isolation & purification*
  • Flavones / pharmacology*
  • Humans
  • Lipase / antagonists & inhibitors
  • Lipase / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Prenylation
  • Stilbenes / chemistry
  • Stilbenes / isolation & purification*
  • Stilbenes / pharmacology*

Substances

  • Enzyme Inhibitors
  • Flavones
  • Plant Extracts
  • Stilbenes
  • Lipase
  • PNLIP protein, human