Abstract
This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps.
MeSH terms
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Alkylation
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Antineoplastic Agents, Alkylating / chemical synthesis*
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Antineoplastic Agents, Alkylating / chemistry
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Ethanolamines / chemistry
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Mechlorethamine / chemical synthesis*
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Mechlorethamine / chemistry
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Molecular Structure
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Thymine / chemistry*
Substances
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Antineoplastic Agents, Alkylating
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Ethanolamines
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Mechlorethamine
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diethanolamine
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Thymine