Abstract
Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Carcinoma, Ductal, Breast / metabolism
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Carcinoma, Ductal, Breast / pathology*
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Female
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Glycation End Products, Advanced / metabolism*
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Humans
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Mitogen-Activated Protein Kinases / biosynthesis*
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Molecular Sequence Data
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NADPH Oxidases / metabolism
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NF-kappa B / metabolism
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Neoplasm Invasiveness
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Neoplasm Proteins / metabolism*
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Protein Processing, Post-Translational
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Receptor for Advanced Glycation End Products / biosynthesis*
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Receptor, ErbB-2 / analysis
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Receptor, ErbB-2 / metabolism
Substances
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Glycation End Products, Advanced
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NF-kappa B
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Neoplasm Proteins
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Receptor for Advanced Glycation End Products
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NADPH Oxidases
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Receptor, ErbB-2
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Mitogen-Activated Protein Kinases