Abstract
Hashimoto encephalitis (HE) is a steroid-responsive autoimmune encephalitis with anti-thyroid antibodies; Creutzfeldt-Jakob disease (CJD) is a prion disease. Both disorders can have a similar clinical presentation. Two women, 67 and 63 year-old, with subacute dementia, ataxia, myoclonus and positive antithyroid antibodies were given oral steroids. Whereas one progressively declined and had histopathologically proven CJD, the other made a complete recovery and was diagnosed with HE. Anti-thyroid antibodies can occur in CJD, but when present in a patient with subacute dementia, ataxia and myoclonus, a steroid trial always seems indicated.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antibodies / analysis
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Ataxia / diagnosis*
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Brain Diseases / diagnosis*
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Brain Diseases / drug therapy
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Cerebrum / pathology
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Creutzfeldt-Jakob Syndrome / diagnosis*
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Creutzfeldt-Jakob Syndrome / drug therapy
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Creutzfeldt-Jakob Syndrome / pathology
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Dementia / diagnosis*
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Diagnosis, Differential
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Encephalitis
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Fatal Outcome
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Female
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Glucocorticoids / therapeutic use
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Hashimoto Disease / diagnosis*
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Hashimoto Disease / drug therapy
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Humans
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Magnetic Resonance Imaging
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Mental Status Schedule
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Middle Aged
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Myoclonus / diagnosis*
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Prednisolone / therapeutic use
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Thyroid Gland / immunology
Substances
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Antibodies
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Glucocorticoids
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Prednisolone