Prediction of eye color from genetic data using Bayesian approach

J Forensic Sci. 2012 Jul;57(4):880-6. doi: 10.1111/j.1556-4029.2012.02077.x. Epub 2012 Feb 28.

Abstract

Prediction of visible traits from genetic data in certain forensic cases may provide important information that can speed up the process of investigation. Research that has been conducted on the genetics of pigmentation has revealed polymorphisms that explain a significant proportion of the variation observed in human iris color. Here, on the basis of genetic data for the six most relevant eye color predictors, two alternative Bayesian network model variants were developed and evaluated for their accuracy in prediction of eye color. The first model assumed eye color to be categorized into blue, brown, green, and hazel, while the second variant assumed a simplified classification with two states: light and dark. It was found that particularly high accuracy was obtained for the second model, and this proved that reliable differentiation between light and dark irises is possible based on analysis of six single nucleotide polymorphisms and a Bayesian procedure of evidence interpretation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antigens, Neoplasm / genetics
  • Antiporters / genetics
  • Eye Color / genetics*
  • Female
  • Forensic Genetics
  • Guanine Nucleotide Exchange Factors / genetics
  • Humans
  • Interferon Regulatory Factors / genetics
  • Linkage Disequilibrium
  • Male
  • Membrane Glycoproteins / genetics
  • Membrane Transport Proteins / genetics
  • Middle Aged
  • Models, Statistical*
  • Multiplex Polymerase Chain Reaction
  • Oxidoreductases / genetics
  • Polymorphism, Single Nucleotide
  • Predictive Value of Tests
  • Probability
  • Sensitivity and Specificity
  • Sequence Analysis, DNA
  • Ubiquitin-Protein Ligases
  • Young Adult

Substances

  • Antigens, Neoplasm
  • Antiporters
  • Guanine Nucleotide Exchange Factors
  • Interferon Regulatory Factors
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • OCA2 protein, human
  • SLC24A4 protein, human
  • SLC45A2 protein, human
  • interferon regulatory factor-4
  • Oxidoreductases
  • TYRP1 protein, human
  • HERC2 protein, human
  • Ubiquitin-Protein Ligases