Abstract
Two new triterpenoid glycosides, mimengosides H (1) and I (2), were isolated from the fruits of Buddleja lindleyana Fort. Their structures were determined by extensive spectroscopic methods. Neuroprotective effects of these isolates against 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells were evaluated. Pretreatment with compound 1 had potential protective effect in a concentration range from 0.1 to 1 μmol l⁻¹.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Buddleja / chemistry*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Fruit / chemistry
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Humans
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology*
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PC12 Cells
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Rats
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Drugs, Chinese Herbal
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Neuroprotective Agents
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Saponins
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Triterpenes
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mimengoside H
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mimengoside I