Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles

Adv Mater. 2012 Apr 10;24(14):1868-72. doi: 10.1002/adma.201104964. Epub 2012 Feb 29.

Abstract

In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ferric Compounds / chemistry
  • Graphite / chemistry*
  • Magnetic Resonance Imaging
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / therapeutic use
  • Mice
  • Nanocomposites / chemistry*
  • Nanocomposites / therapeutic use
  • Neoplasms / diagnosis
  • Neoplasms / therapy
  • Oxidation-Reduction
  • Oxides / chemistry
  • Phototherapy
  • Polyethylene Glycols / chemistry

Substances

  • Ferric Compounds
  • Magnetite Nanoparticles
  • Oxides
  • ferric oxide
  • Polyethylene Glycols
  • Graphite