Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse

Immunol Lett. 2012 May 30;144(1-2):1-6. doi: 10.1016/j.imlet.2012.02.012. Epub 2012 Feb 28.

Abstract

Toll-like receptors appear to play an important role in the pathogenesis of lupus-like nephritis in mice. In human and mouse, CD180 is a homologue of TLR4. In SLE patients, the number of CD180-negative B cells in peripheral blood changes in parallel with disease activity. In the present study using NZBWF1 mice, the population of splenic CD180-negative B cells increased with progression of renal lesions and aging. These cells produced both anti-dsDNA and histone antibodies; the peripheral blood levels of anti-dsDNA antibody increased markedly with aging. B cells infiltrating into renal lesions were CD180-negative and produced anti-dsDNA antibody. Considered together, these findings indicate that CD180-negative B cells contribute significantly to development of SLE-like morbidity in NZBWF1 mice by autoantibody production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / immunology
  • Animals
  • Antigens, CD / metabolism*
  • Autoantibodies / biosynthesis*
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / physiopathology*
  • Autoimmunity
  • B-Lymphocytes / immunology*
  • Cells, Cultured
  • Female
  • Humans
  • Kidney / immunology
  • Kidney / pathology
  • Lupus Nephritis / immunology*
  • Lupus Nephritis / pathology
  • Lupus Nephritis / physiopathology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred NZB
  • Spleen / immunology

Substances

  • Antigens, CD
  • Autoantibodies
  • Ly78 protein, mouse