A case of esomeprazole-induced transient diabetes and hepatitis: the role of liver inflammation in the pathogenesis of insulin resistance

Francesco Zaccardi; Dario Pitocco; Francesca Martini; Salvatore Caputo; Luca Miele; Antonio Grieco; Giovanni Ghirlanda

doi:10.1007/s00592-012-0382-5

A case of esomeprazole-induced transient diabetes and hepatitis: the role of liver inflammation in the pathogenesis of insulin resistance

Acta Diabetol. 2014 Feb;51(1):151-3. doi: 10.1007/s00592-012-0382-5. Epub 2012 Mar 3.

Authors

Francesco Zaccardi¹, Dario Pitocco, Francesca Martini, Salvatore Caputo, Luca Miele, Antonio Grieco, Giovanni Ghirlanda

Affiliation

¹ Diabetes Care Unit, Catholic University, A. Gemelli Hospital, L. Go A. Gemelli, 00168, Rome, Italy, [email protected].

PMID: 22389003
DOI: 10.1007/s00592-012-0382-5

Abstract

We describe a case report of a patient who developed transient type 2 diabetes after a drug-induced (esomeprazole) sub-acute hepatitis. This case evidences the pathophysiological relevance, also in humans, of liver inflammation in the pathogenesis of type 2 diabetes.

Publication types

Case Reports

MeSH terms

Anti-Ulcer Agents / adverse effects*
Chemical and Drug Induced Liver Injury* / diagnosis
Chemical and Drug Induced Liver Injury* / etiology
Chemical and Drug Induced Liver Injury* / metabolism
Diabetes Mellitus, Type 2 / chemically induced*
Esomeprazole / adverse effects*
Humans
Inflammation / complications
Inflammation / metabolism*
Insulin Resistance*
Male
Middle Aged

Substances

Anti-Ulcer Agents
Esomeprazole