Abstract
Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 1-3 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / isolation & purification
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Amines / pharmacology
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Animals
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Cannabaceae / chemistry*
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Carrageenan
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Edema / chemically induced
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Edema / drug therapy
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Fatty Acids / chemistry
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Fatty Acids / isolation & purification
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Fatty Acids / pharmacology
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Female
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Male
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Pentacyclic Triterpenes / chemistry
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Pentacyclic Triterpenes / isolation & purification
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Pentacyclic Triterpenes / pharmacology
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plant Components, Aerial / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Rats
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Rats, Wistar
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Sitosterols / chemistry
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Sitosterols / isolation & purification
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Sitosterols / pharmacology
Substances
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Amines
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Cholinesterase Inhibitors
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Fatty Acids
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Free Radical Scavengers
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Pentacyclic Triterpenes
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Phenols
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Plant Extracts
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Sitosterols
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gamma-sitosterol
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Oleanolic Acid
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Carrageenan
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lupeol