Abstract
In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC₅₀) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bacteria / drug effects
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Bicyclic Monoterpenes
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Bridged Bicyclo Compounds / isolation & purification
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Bridged Bicyclo Compounds / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Cyclohexanols / isolation & purification
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Cyclohexanols / pharmacology
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Drug Screening Assays, Antitumor
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Eucalyptol
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Humans
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Monoterpenes / isolation & purification
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Monoterpenes / pharmacology
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Oils, Volatile / isolation & purification
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Oils, Volatile / pharmacology*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Rosmarinus / chemistry*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Bicyclic Monoterpenes
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Bridged Bicyclo Compounds
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Cyclohexanols
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Monoterpenes
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Oils, Volatile
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Plant Extracts
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beta-pinene
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alpha-pinene
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Eucalyptol