Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies

MeSH terms

• Agammaglobulinaemia Tyrosine Kinase
• Animals
• Anti-Inflammatory Agents / chemistry*
• Anti-Inflammatory Agents / pharmacology
• Antineoplastic Agents / chemistry*
• Antineoplastic Agents / pharmacology
• Catalytic Domain
• Clinical Trials as Topic
• Drug Evaluation, Preclinical
• Drug Industry
• Humans
• Inflammation / drug therapy*
• Inflammation / enzymology
• Leukemia, B-Cell / drug therapy*
• Leukemia, B-Cell / enzymology
• Models, Molecular
• Protein Conformation
• Protein-Tyrosine Kinases / antagonists & inhibitors*
• Protein-Tyrosine Kinases / chemistry
• Structure-Activity Relationship