Anaemia and iron deficiency in children with inflammatory bowel disease

J Crohns Colitis. 2012 Jul;6(6):687-91. doi: 10.1016/j.crohns.2011.12.001. Epub 2012 Jan 17.

Abstract

Background and aims: Anaemia and iron deficiency are common in children with Inflammatory Bowel Disease (IBD) however it is not known if the prevalence of anaemia and iron deficiency alters following diagnosis.

Methods: Laboratory results from diagnosis, and at follow up one and two years later were recorded retrospectively in children with IBD recruited from a tertiary centre. Anaemia was defined using WHO standards and iron deficiency defined using published guidelines.

Results: 46 children (16 girls) with Crohn's disease and 34 children (18 girls) with UC were studied. 75% of children with IBD were anaemic at diagnosis, 30% were anaemic at follow up two years later. 90% of children with Crohn's and 95% of children with Ulcerative Colitis (UC) were iron deficient at diagnosis. At follow up two years later 70% of children with Crohn's and 65% of children with UC were iron deficient.

Conclusions: Persistent anaemia and iron deficiency are common in childhood IBD, prevalence alters with duration of time from diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anemia / blood
  • Anemia / diagnosis
  • Anemia / epidemiology
  • Anemia / etiology*
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • Cohort Studies
  • Colitis, Ulcerative / blood
  • Colitis, Ulcerative / complications*
  • Crohn Disease / blood
  • Crohn Disease / complications*
  • Female
  • Ferritins / blood
  • Follow-Up Studies
  • Humans
  • Iron Deficiencies*
  • Male
  • Prevalence
  • Retrospective Studies
  • Transferrin / metabolism

Substances

  • Biomarkers
  • Transferrin
  • Ferritins

Supplementary concepts

  • Pediatric Crohn's disease