No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students

Changgui Kou; Xiangfei Meng; Bing Xie; Jieping Shi; Qiong Yu; Yaqin Yu; Carl D'Arcy

doi:10.1016/j.psychres.2011.10.020

No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students

Psychiatry Res. 2012 Jul 30;198(2):313-5. doi: 10.1016/j.psychres.2011.10.020. Epub 2012 Mar 7.

Authors

Changgui Kou¹, Xiangfei Meng, Bing Xie, Jieping Shi, Qiong Yu, Yaqin Yu, Carl D'Arcy

Affiliation

¹ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.

PMID: 22401966
DOI: 10.1016/j.psychres.2011.10.020

Abstract

This study investigates the genetic association between catechol-O-methyltransferase (COMT) gene polymorphisms and neurotic disorders. Data were derived from a case-control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag single nucleotide polymorphisms (SNPs) on the COMT gene were tested using polymerase chain reaction (PCR)-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on the COMT gene assessed were not associated with neurotic disorders. Our finding suggests that the COMT gene may not be a susceptibility gene for neurotic disorders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics*
Asian People / psychology
Case-Control Studies
Catechol O-Methyltransferase / genetics*
Female
Genetic Association Studies / methods
Genetic Association Studies / statistics & numerical data*
Genetic Predisposition to Disease / genetics
Humans
Male
Neurotic Disorders / genetics*
Polymorphism, Single Nucleotide*
Students / psychology
Universities*

Substances

Catechol O-Methyltransferase