Abstract
PTLD is a serious and frequently observed complication after solid organ transplantation. We present a six-yr-old girl with a rapidly growing, solid tumor of the lip four yr after orthotopic heart transplantation, which was classified as monomorphic PTLD with the characteristics of a diffuse large B-cell lymphoma. Treatment with reduction in immunosuppression, ganciclovir, and anti B-cell monoclonal antibody (rituximab) resulted in full remission since 12 months. To the best of our knowledge, this report is the first description of PTLD in the lip in a pediatric patient after heart transplantation in the English literature.
© 2012 John Wiley & Sons A/S.
MeSH terms
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Antibodies, Monoclonal, Murine-Derived / pharmacology
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Cardiomyopathies / complications
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Cardiomyopathies / therapy*
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Child
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / diagnosis
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Female
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Ganciclovir / pharmacology
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Heart Failure / complications
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Heart Failure / therapy*
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Heart Transplantation / adverse effects*
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Herpesvirus 4, Human / metabolism
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Humans
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Immunosuppressive Agents / pharmacology
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Lip / immunology*
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Lip Neoplasms / etiology*
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Lip Neoplasms / therapy
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Lymphoma, B-Cell / complications*
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Lymphoma, B-Cell / therapy
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Lymphoproliferative Disorders / complications
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Lymphoproliferative Disorders / diagnosis*
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Postoperative Complications
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Remission Induction
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Rituximab
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Time Factors
Substances
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Antibodies, Monoclonal, Murine-Derived
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Immunosuppressive Agents
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Rituximab
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Ganciclovir