WTX: an unexpected regulator for p53

Mol Cell. 2012 Mar 9;45(5):581-2. doi: 10.1016/j.molcel.2012.02.010.

Abstract

The WTX gene is frequently lost or mutated in Wilms tumor. In this issue of Molecular Cell, Kim et al. (2012) identify WTX modulation of p53 tumor-suppressor activity through regulation of p53 acetylation. Therefore, WTX differentially regulates the oncogenic β-catenin pathway and the tumor-suppressing p53 pathway.

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