PKM2 enters the morpheein academy

Galina Semenova; Jonathan Chernoff

doi:10.1016/j.molcel.2012.02.014

PKM2 enters the morpheein academy

Mol Cell. 2012 Mar 9;45(5):583-4. doi: 10.1016/j.molcel.2012.02.014.

Authors

Galina Semenova¹, Jonathan Chernoff

Affiliation

¹ Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

PMID: 22405271
DOI: 10.1016/j.molcel.2012.02.014

Abstract

In this issue of Molecular Cell, Gao et al. (2012) show that the glycolytic enzyme PKM2, in its dimeric form, possesses protein kinase activity and phosphorylates STAT3 in the nucleus, thereby driving expression of genes that promote transformation.

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