Carbon-dot-based dual-emission nanohybrid produces a ratiometric fluorescent sensor for in vivo imaging of cellular copper ions

Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7185-9. doi: 10.1002/anie.201109089. Epub 2012 Mar 8.

Abstract

A sensitive biosensor: A strategy for the intracellular imaging of Cu(2+) ions has been developed by integrating a recognition molecule, N-(2-aminoethyl)-N,N,N'tris(pyridin-2-ylmethyl)ethane-1,2-diamine (AE-TPEA), into a hybrid system composed of carbon and CdSe/ZnS quantum dots.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • Cadmium Compounds / chemistry
  • Carbon / chemistry*
  • Cations, Divalent / analysis
  • Copper / analysis*
  • Ethylenediamines / chemistry*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Pyridines / chemistry*
  • Quantum Dots*
  • Selenium Compounds / chemistry
  • Spectrometry, Fluorescence / methods
  • Sulfides / chemistry
  • Zinc Compounds / chemistry

Substances

  • Cadmium Compounds
  • Cations, Divalent
  • Ethylenediamines
  • Fluorescent Dyes
  • N-(2-aminoethyl)-N,N,N'-tris(pyridin-2-ylmethyl)ethane-1,2-diamine
  • Pyridines
  • Selenium Compounds
  • Sulfides
  • Zinc Compounds
  • Carbon
  • Copper
  • cadmium selenide
  • zinc sulfide