Abstract
Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that infects most people but results in life-threatening diseases in only a small subset. Persons who are unable to maintain the virus in its latent state can develop uncontrolled EBV-driven lymphoproliferative disorders and lymphomas. EBV-associated lymphomas are well characterized in patients with known defects in cellular immunity as occurs post-transplantation or HIV/AIDS but are increasingly recognized in patients without overt immunodeficiencies. Improved understanding of the biology of these lymphomas and the role EBV plays in lymphomagenesis offer the opportunity for improved therapies targeted at important signaling pathways and immunotherapy specific against EBV viral antigens.
Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / therapeutic use
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Doxorubicin / administration & dosage
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Doxorubicin / therapeutic use
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / immunology
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Epstein-Barr Virus Infections / therapy*
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Epstein-Barr Virus Infections / virology
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Epstein-Barr Virus Nuclear Antigens / genetics
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Epstein-Barr Virus Nuclear Antigens / immunology
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Herpesvirus 4, Human / physiology*
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Humans
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Immunocompetence
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Immunologic Deficiency Syndromes / virology
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Immunotherapy, Adoptive*
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Lymphoma / complications
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Lymphoma / immunology
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Lymphoma / therapy*
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Lymphoma / virology
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Prednisone / administration & dosage
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Prednisone / therapeutic use
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T-Lymphocytes, Cytotoxic / immunology*
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T-Lymphocytes, Cytotoxic / transplantation
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Vincristine / administration & dosage
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Vincristine / therapeutic use
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Viral Matrix Proteins / genetics
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Viral Matrix Proteins / immunology
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Virus Latency / genetics
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Virus Latency / immunology
Substances
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Epstein-Barr Virus Nuclear Antigens
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Viral Matrix Proteins
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone