Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321

Yongxiang Song; Jiajian Wang; Hongbo Huang; Lin Ma; Jun Wang; Yucheng Gu; Lan Liu; Yongcheng Lin

doi:10.3390/md10020340

Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321

Mar Drugs. 2012 Feb;10(2):340-348. doi: 10.3390/md10020340. Epub 2012 Feb 6.

Authors

Yongxiang Song^{1

2}, Jiajian Wang¹, Hongbo Huang^{1

2}, Lin Ma¹, Jun Wang^{3

4}, Yucheng Gu⁵, Lan Liu^{1

3}, Yongcheng Lin^{1

3}

Affiliations

¹ School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.
² CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Rd., Guangzhou 510301, China.
³ Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education of Guangdong, Guangzhou, 510275, China.
⁴ School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China.
⁵ Syngenta Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK.

Abstract

Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM.

Keywords: Xylaria sp.; mangrove; marine fungus; sesquiterpenes; α-glucosidase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / metabolism
Anti-Bacterial Agents / pharmacology*
Aquatic Organisms / isolation & purification
Aquatic Organisms / metabolism*
Avicennia / microbiology
Chromatography, High Pressure Liquid
Drug Discovery
Endophytes / isolation & purification
Endophytes / metabolism*
Enzyme Activation / drug effects
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / metabolism
Enzyme Inhibitors / pharmacology
Eremophila Plant / microbiology
Fermentation
Glycoside Hydrolase Inhibitors
Inhibitory Concentration 50
Molecular Structure
Naphthalenes / chemistry
Naphthalenes / isolation & purification
Naphthalenes / metabolism
Naphthalenes / pharmacology
Pseudomonas aeruginosa / drug effects
Rhizophoraceae / microbiology
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / metabolism
Sesquiterpenes / pharmacology*
Spectrometry, Mass, Electrospray Ionization
Staphylococcus aureus / drug effects
Xylariales / isolation & purification
Xylariales / metabolism*
alpha-Glucosidases / chemistry
alpha-Glucosidases / metabolism

Substances

07H239-A
Anti-Bacterial Agents
Enzyme Inhibitors
Glycoside Hydrolase Inhibitors
Naphthalenes
Sesquiterpenes
alpha-Glucosidases