Abstract
Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
© 2012 New York Academy of Sciences.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Drug-Related Side Effects and Adverse Reactions* / genetics
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Drug-Related Side Effects and Adverse Reactions* / metabolism
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Gene Regulatory Networks / genetics*
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Humans
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Pharmaceutical Preparations / metabolism
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Precision Medicine / methods
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Precision Medicine / trends
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Systems Biology / methods*
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Systems Biology / trends
Substances
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Pharmaceutical Preparations