Constructing unit-specific empiric treatment guidelines for catheter-related and primary bacteremia by determining the likelihood of inadequate therapy

Infect Control Hosp Epidemiol. 2012 Apr;33(4):416-20. doi: 10.1086/664756.

Abstract

This study aimed to determine the feasibility of using likelihood of inadequate therapy (LIT), a parameter calculated by using pathogen frequency and in vitro susceptibility for determination of appropriate empiric antibiotic therapy for primary bloodstream infections. Our study demonstrates that LIT may reveal differences in traditional antibiograms.

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteremia / drug therapy*
  • Bacteremia / microbiology
  • Catheter-Related Infections / drug therapy*
  • Catheter-Related Infections / microbiology
  • Feasibility Studies
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Microbial Sensitivity Tests / methods
  • Middle Aged
  • Penicillanic Acid / analogs & derivatives
  • Penicillanic Acid / therapeutic use
  • Piperacillin / therapeutic use
  • Piperacillin, Tazobactam Drug Combination
  • Practice Guidelines as Topic*
  • Retrospective Studies
  • Treatment Failure

Substances

  • Anti-Bacterial Agents
  • Piperacillin, Tazobactam Drug Combination
  • Penicillanic Acid
  • Piperacillin